Electrochemical sensor based on glassy carbon electrode modified by polymelamine formaldehyde/graphene oxide nanocomposite for ultrasensitive detection of oxycodone.
Hossein KhosropourBehzad RezaeiHossein A AlinajafiAli A EnsafiPublished in: Mikrochimica acta (2021)
Polymelamine formaldehyde/graphene oxide (PMF/GO) nanocomposite was used, for the first time, to study the ultrasensitive and selective electrochemical detection of oxycodone (OXC). The successful characterization of PMF/GO was verified based on scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), energy-dispersive spectroscopy (EDS), and Raman spectroscopy. The modified GCE (PMF/GO-GCE) proved its electrocatalytic effect on OXC determination according to cyclic, linear sweep, and differential pulse voltammetry (CV, LSV, and DPV) and electrochemical impedance spectroscopy (EIS) studies. The developed sensor under optimal conditions offered a linear relationship in a limited range of 0.01 to 45 μmol L-1 with the limit of detection (LOD) of 2.0 nmol L-1. The proposed PMF/GO-GCE sensor was effectively employed for the OXC detection in human urine and serum samples. Graphical abstract.
Keyphrases
- electron microscopy
- label free
- molecularly imprinted
- gold nanoparticles
- solid phase extraction
- high resolution
- loop mediated isothermal amplification
- real time pcr
- quantum dots
- ionic liquid
- reduced graphene oxide
- raman spectroscopy
- endothelial cells
- single molecule
- room temperature
- blood pressure
- solid state
- magnetic resonance imaging
- mass spectrometry
- highly efficient
- tandem mass spectrometry
- metal organic framework