Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS.

Johanna OechteringTherese LinckeSabine SchaedelinBernhard F DécardAleksandra MaceskiAnnette OrlethStephanie MeierEline WillemseArabella BuchmannMicheal KhalilTobias DerfussPascal BenkertIngmar HeijnenAxel RegeniterStefanie MüllerLutz AchtnichtsPatrice LaliveAnke SalmenCaroline PotClaudio GobbiLudwig KapposCristina GranzieraDavid LeppertRegina SchlaegerJohanna M LiebJens Kuhlenull null

Published in: Annals of neurology (2022)

Intrathecal IgM synthesis is strongly associated with spinal manifestation and independently more pronounced neuroaxonal injury in early MS, suggesting a distinct clinical phenotype and pathophysiology. ANN NEUROL 2022;91:814-820.

Keyphrases

spinal cord
mass spectrometry
multiple sclerosis
ms ms
spinal cord injury
neuropathic pain
blood brain barrier
brain injury