Entecavir resistance mutations rtL180M/T184L/M204V combined with rtA200V lead to tenofovir resistance.
Dong JiangJianghua WangXuesen ZhaoYuxin LiQun ZhangChuan SongHui ZengXian-Bo WangPublished in: Liver international : official journal of the International Association for the Study of the Liver (2019)
An rtL180M/T184L/A200V/M204V mutant with moderate resistance to TDF monotherapy was selected during sequential nucleoside analogue (NA) treatment in a stepwise manner. ETV/TDF combination therapy effectively suppressed replication of this TDF-resistant mutant. Our studies provide novel insights into the treatment of NA-naïve patients as well as patients with TDF resistance.