Treatment effects of fingolimod in multiple sclerosis: Selective changes in peripheral blood lymphocyte subsets.
Maria HjorthNicolae DanduJohan MellergårdPublished in: PloS one (2020)
Our results confirm that fingolimod therapy markedly reduces lymphocyte counts in peripheral blood of MS patients. Subgroup analysis of T cells showed that naïve and CM Th cells were the most profoundly affected and that memory Tregs were relatively preserved.
Keyphrases
- peripheral blood
- multiple sclerosis
- end stage renal disease
- white matter
- induced apoptosis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- mass spectrometry
- cell cycle arrest
- prognostic factors
- stem cells
- working memory
- patient reported outcomes
- clinical trial
- endoplasmic reticulum stress
- bone marrow
- cell proliferation
- oxidative stress
- signaling pathway
- pi k akt