Retargeting azithromycin analogues to have dual-modality antimalarial activity.
Amy L BurnsBrad E SleebsGhizal SiddiquiAmanda E De PaoliDovile AndersonBenjamin LiffnerRichard HarveyJames G BeesonDarren J CreekChristopher D GoodmanGeoffrey I McFaddenDanny W WilsonPublished in: BMC biology (2020)
We show that azithromycin and analogues can rapidly kill malaria parasite asexual blood stages via a fast action mechanism. Development of azithromycin and analogues as antimalarials offers the possibility of targeting parasites through both a quick-killing and delayed-death mechanism of action in a single, multifactorial chemotype.