Association of Genetic Variants for Plasma LRG1 With Rapid Decline in Kidney Function in Patients With Type 2 Diabetes.

Resham Lal GurungRajkumar DorajooYiamunaa MJian-Jun LiuSharon Li Ting PekJiexun WangLing WangXueling S SimSylvia LiuYi-Ming ShaoKeven AngTavintharan SubramaniamWern Ee TangChee Fang SumJian-Jun LiuJian-Jun Liu

Published in: The Journal of clinical endocrinology and metabolism (2021)

We demonstrate that genetically influenced plasma LRG1 increases the risk of RDKF in T2D patients, suggesting plasma LRG1 as a potential treatment target. However, further studies are warranted to elucidate underlying pathways to provide insight into diabetic kidney disease prevention.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
type diabetes
prognostic factors
patient reported outcomes
risk assessment
climate change
loop mediated isothermal amplification
patient reported
replacement therapy