Proanthocyanidins inhibit the apoptosis and aging of nucleus pulposus cells through the PI3K/Akt pathway delaying intervertebral disc degeneration.

Hai-Wei Chen Ming-Qiang Liu Guang-Zhi ZhangCang-Yu ZhangZhao-Heng WangAi-Xin LinJi-He KangWen-Zhao LiuXu-Dong GuoYi-Dian WangXue-Wen Kang

Published in: Connective tissue research (2022)

The results of the present study showed that PACs inhibit IL-1β-induced apoptosis and aging of NP cells by activating the PI3K/Akt pathway, and suggested that PACs have therapeutic potential for IDD.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell cycle arrest
pi k akt
cell death
cell proliferation