Enhanced Glutaminolysis Drives Hypoxia-Induced Chemoresistance in Pancreatic Cancer.

Seung Joon Park Hee Chan Yoo Eunyong Ahn Enzhi Luo Yeabeen Kim Yulseung Sung Ya Chun Yu Kibum Kim Do Sik Min Hee Seung Lee Geum-Sook Hwang TaeJin Ahn Junjeong Choi Seungmin Bang Jung Min Han

Published in: Cancer research (2023)

Increased glutaminolysis induces hypoxia via oxidative phosphorylation-mediated oxygen consumption and drives chemoresistance in pancreatic cancer, revealing a potential therapeutic strategy of combining glutaminolysis inhibition and chemotherapy to overcome resistance.

Keyphrases

endothelial cells
locally advanced
cancer stem cells
protein kinase
radiation therapy