Elevated Plasma Aβ42 in Cognitively Impaired Individuals Taking ACE Inhibitor Antihypertensives.
William T RegenoldJacob B BlumenthalDavid J LoreckKristen L MordecaiGina ScarinziSeshagiri R DoddiLawrence AdlerPublished in: American journal of Alzheimer's disease and other dementias (2017)
This study is the first to show an association between ACE-I use and increased plasma Aβ42 level and Aβ42/Aβ40 ratio in cognitively impaired individuals. Future investigations should assess whether a possible ACE-I-induced increase in plasma Aβ42 indicates improved Aβ42 clearance from brain that contributes to protection from cognitive decline.