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Identification of Cancer-associated metabolic vulnerabilities by modeling multi-objective optimality in metabolism.

Ziwei DaiShiyu YangLiyan XuHongrong HuKun LiaoJianghuang WangQian WangShuaishi GaoBo LiLuhua Lai
Published in: Cell communication and signaling : CCS (2019)
These results confirm this multi-objective optimization model as a novel and effective approach for studying trade-off between metabolic demands of cancer cells and identifying cancer-associated metabolic vulnerabilities, and suggest novel metabolic targets for cancer treatment.
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