Prevalence and Predictors of CD4+ T-Lymphocytopenia Among HIV-Negative Tuberculosis Patients in Uganda.
Joseph Baruch BalukuJoseph MusaaziRose MulwanaAraali Robert MugaboFelix BongominWinceslaus KatagiraPublished in: Research and reports in tropical medicine (2020)
There was a high prevalence of CD4+ T-lymphocytopenia among HIV-negative TB patients. Patients with weight loss, anaemia and a low CD8+ count were more likely to have CD4+ T-lymphocytopenia while those with monocytosis were less likely to have CD4+ lymphocytopenia. The findings suggest that CD4+ lymphocytopenia is indicative of severe disease and globally impaired cell-mediated immune responses against TB.
Keyphrases
- end stage renal disease
- immune response
- ejection fraction
- weight loss
- mycobacterium tuberculosis
- nk cells
- hepatitis c virus
- chronic kidney disease
- antiretroviral therapy
- hiv infected
- peritoneal dialysis
- human immunodeficiency virus
- stem cells
- type diabetes
- early onset
- body mass index
- risk factors
- insulin resistance
- roux en y gastric bypass
- toll like receptor
- mesenchymal stem cells
- drug induced
- electronic health record
- patient reported
- gastric bypass
- obese patients