The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3.

Tomotake KanaiNaoki KondoMasayasu OkadaHiroshige SanoGo OkumuraYasufumi KijimaAkira OgoseHiroyuki KawashimaNaoto Endo

Published in: Journal of orthopaedic surgery and research (2020)

We demonstrated the existence of an MMP-3 suppression mechanism that utilizes the JNK pathway in RA-FLS. We consider that the JNK pathway could be a target for future RA therapies.

Keyphrases

rheumatoid arthritis
signaling pathway
cell death
disease activity
induced apoptosis
ankylosing spondylitis
interstitial lung disease
systemic lupus erythematosus
cell migration
current status