Intratumor expanded T cell clones can be non-sentinel lymph node derived in breast cancer revealed by single-cell immune profiling.

Shiping JiaoQing XiongMeisi YanXiaolu ZhanZhenhuang YangCheng PengBeicheng SunDa PangTong Liu

Published in: Journal for immunotherapy of cancer (2022)

Our study revealed expanded intratumor non-sentinel LN derived T cell clones located in the TLS, which points to the need for exploring the role of TLS in antitumor immunity.

Keyphrases

single cell
sentinel lymph node
rna seq
lymph node
early stage
neoadjuvant chemotherapy
high throughput
squamous cell carcinoma
young adults
radiation therapy