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Inhibition of the Progression of Skin Inflammation, Fibrosis, and Vascular Injury by Blockade of the CX3 CL1/CX3 CR1 Pathway in Experimental Mouse Models of Systemic Sclerosis.

Vu H LuongAkira UtsunomiyaTakenao ChinoLe H DoanhTakashi MatsushitaTakashi ObaraYoshikazu KuboiNaoto IshiiAkihito MachinagaHideaki OgasawaraWataru IkedaTetsu KawanoToshio ImaiNoritaka OyamaMinoru Hasegawa
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
Anti-CX3 CL1 mAb therapy may be a novel approach for treating early skin fibrosis in inflammation-driven fibrotic skin disorders such as SSc.
Keyphrases
  • systemic sclerosis
  • interstitial lung disease
  • soft tissue
  • oxidative stress
  • wound healing
  • mouse model
  • stem cells
  • idiopathic pulmonary fibrosis
  • mesenchymal stem cells
  • cell therapy