Electrospray ionization mass spectrometry ion suppression/enhancement caused by column bleed for three mixed-mode reversed-phase/anion-exchange high-performance liquid chromatography columns.
Thomas H WalterMelvin Blaze M TCheryl BoisselPublished in: Rapid communications in mass spectrometry : RCM (2021)
The low levels of mass spectrometry ion suppression or enhancement caused by column bleed from the hybrid particle-based columns should allow for accurate quantitative mass spectrometric detection combined with mixed-mode reversed-phase/weak anion-exchange chromatography.