Exogenous glucagon-like peptide 2 counteracts exogenous cholecystokinin-induced gallbladder contraction in healthy men.
Andreas H LangeNina L HansenMiriam G PedersenHenriette H NerildJens F RehfeldBolette HartmannJens J HolstAnne-Marie Gade EllegaardFilip K Krag KnopPublished in: The Journal of clinical endocrinology and metabolism (2024)
Exogenous GLP-2 counteracts exogenous CCK-induced gallbladder emptying in healthy men, pointing to a possible therapeutic potential for GLP-2 as a relaxing modulator of gallbladder smooth muscle tone (e.g., as bridge to surgery in biliary colic). The effect may also explain the gallbladder-related adverse events reported for GLP-2 receptor agonists used in the treatment of short bowel syndrome.