Unraveling the Role of Sex in Endothelial Cell Dysfunction: Evidence From Lineage Tracing Mice and Cultured Cells.

Junchul ShinJunyoung HongJonnelle M EdwardsIrene KrukovetsSvyatoslav Tkachenko Maria L Adelus Casey E Romanoski Sanjay Rajagopalan Eugene A Podrez Tatiana V ByzovaOlga Stenina-AdongraviOlga A Cherepanova

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

Our study delineates critical sex-specific differences in EC relevant to proinflammatory, pro-oxidant, and angiogenic characteristics, which are entirely consistent with a vulnerable phenotype in females. Our results provide a biological basis for sex-specific proatherosclerotic mechanisms.

Keyphrases

endothelial cells
induced apoptosis
cell cycle arrest
anti inflammatory
oxidative stress
single cell
high fat diet induced
type diabetes
endoplasmic reticulum stress
metabolic syndrome
adipose tissue
signaling pathway
high glucose