Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte-mediated immune suppression.

Ryota TakahashiMarina MacchiniMasaki SunagawaZhengyu JiangTakayuki TanakaGiovanni ValentiBernhard W RenzRuth A WhiteYoku HayakawaC Benedikt WestphalenYagnesh TailorAlina C IugaTamas A GondaJeanine GenkingerKenneth P OliveTimothy C Wang

Published in: Gut (2020)

We show here that IL-1β promotes tumorigenesis in part by inducing an expansion of immune-suppressive B cells. These findings point to the growing significance of B suppressor cells in pancreatic tumorigenesis.

Keyphrases

induced apoptosis
cell cycle arrest
high glucose
diabetic rats
oxidative stress
cell death
drug induced
endothelial cells
stress induced