Asthma inflammatory phenotypes on four continents: most asthma is non-eosinophilic.

Lucy PembreyCollin BrooksHarriet MpairweCamila A FigueiredoAida Y OviedoMartha ChicoHajar AliIrene NambuyaPius TumwesigeSteven RobertsonCharlotte E RutterKarin van VeldhovenSusan RingMauricio L BarretoPhilip J CooperJohn HendersonAlvaro A CruzJeroen DouwesNeil Pearcenull null

Published in: International journal of epidemiology (2022)

This is the first time that sputum induction has been used to compare asthma inflammatory phenotypes in HICs and LMICs. Most cases were non-eosinophilic, including in settings where corticosteroid use was low. A lower prevalence of EA was observed in the LMICs than in the HICs. This has major implications for asthma prevention and management, and suggests that novel prevention strategies and therapies specifically targeting non-eosinophilic asthma are required globally.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
cystic fibrosis
mycobacterium tuberculosis
risk factors
cancer therapy