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Latest developments in engineered skeletal muscle tissues for drug discovery and development.

Serge OstrovidovMurugan RamalingamHojae BaeGorka OriveToshinori FujieXuetao ShiHirokazu Kaji
Published in: Expert opinion on drug discovery (2022)
models of skeletal muscle tissues have been fabricated. Important developments have been made in stem cell research and in the engineering of human skeletal muscle tissue. Some platforms have already started to be used for drug testing, notably those based on the parameters of hypertrophy/atrophy and the contractibility of myotubes. More developments are expected through the use of multicellular types and multi-materials as matrices . The validation and use of these models in drug testing should now increase.
Keyphrases
  • skeletal muscle
  • drug discovery
  • stem cells
  • insulin resistance
  • gene expression
  • endothelial cells
  • adverse drug
  • induced pluripotent stem cells
  • emergency department
  • electronic health record