Haplotypes in the CYP2R1 gene are associated with levels of 25(OH)D and bone mineral density, but not with other markers of bone metabolism (MrOS Sweden).

Anne BjörkDan MellströmClaes OhlssonMagnus KarlssonHans MallminGunnar JohanssonÖsten LjunggrenAndreas Kindmark

Published in: PloS one (2018)

Common variants in the CYP2R1 gene encoding Vitamin D 25-hydroxylase correlate with levels of circulating 25(OH)D but do not otherwise associate with measures of calcium and phosphate homeostasis. Presence of the specific haplotypes may be an indicator of risk for low 25(OH)D levels, and may in addition be correlated to bone mineral density.

Keyphrases

bone mineral density
postmenopausal women
body composition
copy number
genome wide
gene expression
dna methylation