Patch test-relevant concentrations of metal salts cause localized cytotoxicity, including apoptosis, in skin ex vivo.
Yan ZhangNiels P J de GraafRosalien VeldhuizenSanne RoffelSander W SpiekstraThomas RustemeyerCees J KleverlaanAlbert J FeilzerHetty BontkesDongmei DengSusan GibbsPublished in: Contact dermatitis (2021)
The patch test in itself may be damaging to the skin of the patient being tested. These results need further verification with biopsies obtained during clinical patch testing. The future challenge is to remain above the elicitation threshold at noncytotoxic metal concentrations.