Levetiracetam: A Potent Sword against Microglia Polarization in Gliomas.

Xiaoteng Cui Qixue Wang Xiaomin Liu Chun-Sheng Kang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Crosstalk between tumor cells and peritumoral cells contributes to immunosuppressive microenvironment formation in glioblastomas (GBM). A recent study revealed that glioma stem cells activated neuronal activity to promote microglial M2 polarization, leading to GBM progression, which could be pharmacologically blocked by levetiracetam, providing a practical strategy for GBM immunotherapy. See related article by Guo et al., p. 1160.

Keyphrases

stem cells
inflammatory response
induced apoptosis
neuropathic pain
cell cycle arrest
high grade
lipopolysaccharide induced
single cell
mesenchymal stem cells
cell death
blood brain barrier