Molecular Interactions for the Curcumin-Polymer Complex with Enhanced Anti-Inflammatory Effects.
Yan HeHongfei LiuWangqing BianYue LiuXinyang LiuShijing MaXi ZhengZhiyun DuKun ZhangDefang OuyangPublished in: Pharmaceutics (2019)
The molecular interactions between compound and polymeric carriers are expected to highly contribute to high drug load and good physical stability of solid dispersions. In this study, a series of amorphous solid dispersions (ASD) of Curcumin (Cur) were prepared with different polymers by the solvent evaporation method. With the carrier polyvinylpyrrolidone (PVP), the amorphous solid dispersion system exhibits a better solubility and stability than that with poloxamers and HP-β-CD due to the strong drug-polymer interaction. The drug/polymer interaction and their binding sites were investigated by combined experimental (XRD, DSC, FTIR, SEM, Raman, and 1H-NMR) and molecular dynamics simulation techniques. The Curcumin ASD demonstrated enhanced bioavailability by 11-fold and improved anti-inflammatory activities by the decrease in cytokine production (MMP-9, IL-1β, IL-6, VEGF, MIP-2, and TNF-α) compared to the raw Curcumin. The integration of experimental and modeling techniques is a powerful tool for the rational design of formulation development.
Keyphrases
- molecular dynamics simulations
- autism spectrum disorder
- anti inflammatory
- drug delivery
- attention deficit hyperactivity disorder
- adverse drug
- magnetic resonance
- drug induced
- rheumatoid arthritis
- room temperature
- mental health
- intellectual disability
- endothelial cells
- high resolution
- vascular endothelial growth factor
- physical activity
- emergency department
- ionic liquid
- single molecule
- drug release
- solar cells