Functional neuroanatomical associations of working memory in early-onset Alzheimer's disease.

Christopher KobyleckiCathleen HaenseJennifer M HarrisCheryl L StopfordShailendra H SegobinMatthew JonesAnna M T RichardsonAlexander GerhardJosé Anton-RodriguezJennifer C ThompsonKarl HerholzJulie S Snowden

Published in: International journal of geriatric psychiatry (2017)

Our findings support the hypothesis that working memory changes in early-onset Alzheimer's disease are related to temporoparietal rather than frontal hypometabolism and show dissociation from episodic memory performance. They further support the concept of subtypes of Alzheimer's disease with distinct cognitive profiles due to prominent neocortical dysfunction early in the disease course. Copyright © 2017 John Wiley & Sons, Ltd.

Keyphrases

working memory
early onset
late onset
transcranial direct current stimulation
attention deficit hyperactivity disorder
oxidative stress