Structure determination needs to go viral.

Matheus de Bastos Balbe E Gutierres Conrado Pedebos Paula Bacaicoa-Caruso Rodrigo Ligabue Braun

Published in: Amino acids (2024)

Viral diseases are expected to cause new epidemics in the future, therefore, it is essential to assess how viral diversity is represented in terms of deposited protein structures. Here, data were collected from the Protein Data Bank to screen the available structures of viruses of interest to WHO. Excluding SARS-CoV-2 and HIV-1, less than 50 structures were found per year, indicating a lack of diversity. Efforts to determine viral structures are needed to increase preparedness for future public health challenges.

Keyphrases

sars cov
public health
high resolution
respiratory syndrome coronavirus
current status
electronic health record
big data
hiv infected
hiv positive
hiv aids
hiv testing
quality improvement
binding protein
men who have sex with men
artificial intelligence
mass spectrometry
deep learning
data analysis
south africa