Concomitant medication of cetirizine in advanced melanoma could enhance anti-PD-1 efficacy by promoting M1 macrophages polarization.

Domenico MallardoEster SimeoneVito VanellaMaria Grazia VitaleMarco PallaLuigi ScarpatoMiriam PaoneTeresa De CristofaroValentina BorzilloAlessio CortelliniFrancesca SparanoSandro PignataFrancesco FioreCorrado CaracòPiera MaiolinoAntonella PetrilloErnesta CavalcantiSecondo LastoriaPaolo MutoAlfredo BudillonSarah WarrenPaolo Antonio Ascierto

Published in: Journal of translational medicine (2022)

This retrospective study suggests that M1 macrophage polarization may be induced by cetirizine through the interferon-gamma pathway. This effect may synergize with the immunotherapy of advanced melanoma with anti-PD-1 agents.

Keyphrases

skin cancer
healthcare
dendritic cells
adverse drug
immune response