Metformin improves blood glucose by increasing incretins independent of changes in gluconeogenesis in youth with type 2 diabetes.
Celeste K L CravalhoAbby G MeyersLilian S MabundoAmber CourvilleShanna YangHongyi CaiYuhai DaiMary WalterPeter J WalterSusan SharmaShaji ChackoFran CogenSheela N MaggeMorey W HaymondStephanie T ChungPublished in: Diabetologia (2020)
Overall, the improved postprandial blood glucose levels and increase in incretins observed in the absence of changes in insulin sensitivity and gluconeogenesis, support an enteroinsular mechanistic pathway in youth with type 2 diabetes treated with short-term metformin.