Albumin Reduces Oxidative Stress and Neuronal Apoptosis via the ERK/Nrf2/HO-1 Pathway after Intracerebral Hemorrhage in Rats.

Shuixiang DengShengpeng LiuPeng JinShengjie FengMi TianPengju WeiHongda ZhuJiaying TanFeng ZhaoYe Gong

Published in: Oxidative medicine and cellular longevity (2021)

Albumin attenuated oxidative stress-related neuronal death may in part via the ERK/Nrf2/HO-1 signaling pathway after ICH in rats. Our study suggests that albumin may be a novel therapeutic method to ameliorate brain injury after ICH.

Keyphrases

oxidative stress
brain injury
pi k akt
signaling pathway
cerebral ischemia
subarachnoid hemorrhage
cell cycle arrest
induced apoptosis
diabetic rats
dna damage
cell proliferation
ischemia reperfusion injury
epithelial mesenchymal transition
heat shock
cell death
drug induced