Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation.

Henrique José Cardoso Marília I Figueira Cátia Vicente Vaz Tiago Miguel Amaral CarvalhoLuís A BrásPatrícia Alexandra Madureira Paulo J Oliveira Vilma A Sardão Sílvia Socorro

Published in: Cellular oncology (Dordrecht) (2021)

Our data reveal glutaminolysis as a central metabolic route controlling PCa cell fate and highlight the relevance of targeting glutaminase for CRPC treatment.

Keyphrases

cell fate
electronic health record
genome wide
big data
combination therapy
artificial intelligence
data analysis