Cytotrophoblasts suppress macrophage-mediated inflammation through a contact-dependent mechanism.
Alison J EastmanErin N VranaMaria T GrimaldoAmanda D JonesLisa M RogersDonald J AlcendorDavid M AronoffPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)
CTBs limit Mφ NF-κB activation and production of TNF-α and MMP9 through an as-yet unknown, cell-to-cell contact-mediated mechanism. This suppression is distinct from the PGE2 -mediated Mφ TNF-α suppression by DSC, suggesting that DSCs and CTBs regulate Mφ inflammation through distinct mechanisms. How Mφ integrates these signals in an intact GM will be paramount to determining causes and prevention of PPROM.