Selective photodynamic eradication of senescent cells with a β-galactosidase-activated photosensitiser.

Junlong XiongYing-Kit CheungWing-Ping Fong Clarence T T Wong Dennis K P Ng

Published in: Chemical communications (Cambridge, England) (2023)

A β-galactosidase-responsive photosensitiser has been designed and synthesised. It contains a galactosyl substrate, a boron dipyrromethene-based photosensitising unit and a black hole quencher 2 connected via an AB 2 -type self-immolative linker. This novel photosensitiser can be selectively activated by the senescence-associated β-galactosidase in senescent cells, leading to restoration in fluorescence emission and effective killing of the cells via photodynamic action.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cancer therapy
signaling pathway
cell death
dna damage
endothelial cells
cell proliferation
pi k akt
single molecule
energy transfer
structural basis
solar cells