Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [ 11 C]SMW139 and [ 18 F]F-DPA.

Obada M AlzghoolRichard AarnioJatta S HelinSaara WahlroosThomas KellerMarkus MatilainenJunel SolisJonathan J DanonMichael KassiouAnniina SnellmanOlof SolinJuha O RinneMerja Haaparanta-Solin

Published in: EJNMMI research (2024)

F]F-DPA targeting TSPO was more suitable for imaging reactive glia and neuroinflammatory processes in the APP/PS1-21 mouse model, based on the findings presented in this study and previous studies with this mouse model.

Keyphrases

mouse model
pet imaging
positron emission tomography
high resolution
spinal cord injury
drug delivery
mass spectrometry
case control
cancer therapy