Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells.

Annika R SeddonYusmiati LiauPaul E PaceAllison L MillerAndrew B DasMartin A KennedyMark B HamptonAaron J Stevens

Published in: Epigenetics & chromatin (2021)

This research indicates that increased exposure to H2O2 can result in long-term alterations to DNA methylation patterns, providing a mechanism for environmental factors to have prolonged impact on gene expression.

Keyphrases

dna methylation
hydrogen peroxide
genome wide
gene expression
induced apoptosis
nitric oxide
cell cycle arrest
copy number
endoplasmic reticulum stress
oxidative stress
cell proliferation
cell death