Cytotoxic activity of crude extracts from Datura stramonium's fungal endophytes against A549 lung carcinoma and UMG87 glioblastoma cell lines and LC-QTOF-MS/MS based metabolite profiling.

Kudzanai Ian TapfumaNkemdinma Uche-OkereaforTendani Edith SebolaRaeesa HussanLukhanyo MekutoMaya Mellisa MakatiniEzekiel GreenVuyo Mavumengwana

Published in: BMC complementary and alternative medicine (2019)

The findings in this study suggest that the crude extract of Alternaria sp. KTDL7 possesses compound(s) cytotoxic to glioblastoma multiforme cells. Future studies to isolate and characterize the cytotoxic compound(s) from this fungus could result in lead development of a fungal-based drug for glioblastoma multiforme treatment.

Keyphrases

ms ms
induced apoptosis
oxidative stress
cell cycle arrest
emergency department
current status
simultaneous determination
anti inflammatory
endoplasmic reticulum stress
cell death
combination therapy
liquid chromatography
smoking cessation