miR-486-5p protects against rat ischemic kidney injury and prevents the transition to chronic kidney disease and vascular dysfunction.
Adrianna DouvrisJose L ViñasAlex A GutsolJoseph ZimpelmannDylan BurgerKevin D BurnsPublished in: Clinical science (London, England : 1979) (2024)
In rats, administration of miR-486-5p early after kidney IR prevents injury, and protects against CKD development and systemic endothelial dysfunction. These protective effects are associated with inhibition of endothelial ICAM-1 and occur despite reduction in eNOS. miR-486-5p holds promise for the prevention of ischemic AKI and its complications.