Multigene panel testing for hereditary breast and ovarian cancer in the province of Ontario.
Jordan Lerner- EllisChloe MightonConxi LazaroNicholas WatkinsVanessa Di GioacchinoAndrew WongMartin C ChangGeorge S CharamesPublished in: Journal of cancer research and clinical oncology (2020)
Our overall positive yield is similar to that reported in the literature. The yield of inconclusive results was three times that of positive results. By testing more individuals in families with HBOC and through data-sharing efforts, the clinical significance of most variants may eventually be determined and panel testing for monogenic cancer predisposition syndromes will have greater utility.