Tachycardia evoked from insular stroke in rats is dependent on glutamatergic neurotransmission in the dorsomedial hypothalamus.

Fernanda Ribeiro MarinsMarcelo Limborço-FilhoJennifer A IddingsCarlos Henrique XavierVinicia C BiancardiJavier E SternJuan Ramiro DiazStephen M OppenheimerJessica A FilosaMarco Antônio Peliky Fontes

Published in: European journal of neurology (2021)

The iIC-induced tachycardia is largely dependent upon a glutamatergic relay in the DMH. Our study reveals the presence of an excitatory glutamatergic pathway from the iIC to the DMH that may be involved in the cardiovascular alterations observed after insular stroke.

Keyphrases

atrial fibrillation
catheter ablation
diabetic rats
cerebral ischemia
prefrontal cortex
brain injury
blood brain barrier
endothelial cells
stress induced