Development of a High-Dose Infant Air-Jet Dry Powder Inhaler (DPI) with Passive Cyclic Loading of the Formulation.

Connor HoweMohammad A M MominGhali AladwaniMichael HindlePhilip Worth Longest

Published in: Pharmaceutical research (2022)

The infant air-jet DPI platform was successfully modified with a passive cyclic loading strategy and capable of providing an estimated > 60% lung delivery efficiency of a model spray-dried formulation with negligible sensitivity to powder mass loading in the range of 10-30 mg and could be scaled to deliver much higher doses.

Keyphrases

high dose
high frequency
drug delivery
low dose
high throughput
stem cell transplantation