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Mohs micrographic surgery in dermatofibrosarcoma protuberans: Rate and risk factors for recurrence in a prospective cohort study from the Spanish Registry of Mohs Surgery (REGESMOHS) and review of the literature.

Lula María Nieto-BenitoCristina Ciudad-BlancoOnofre Sanmartin-JimenezJoan R GarcesManuel A Rodríguez-PrietoEva VilarrasaEsther de Eusebio-MurilloRomán Miñano-MedranoBegoña Escutia-MuñozBeatriz Gonzalez-SixtoJuan L Artola-IgarzaAlberto Alfaro RubioPedro RedondoYolanda Delgado-JiménezJulia M Sánchez-SchmidtIrati Allende-MarkixanaMaría L Alonso-PachecoBeatriz García-BracamontePablo de la Cueva DobaoRaquel Navarro-TejedorRicardo Suarez-FernándezLucia Carnero-GonzálezHugo Vázquez-VeigaLucia Barchino-OrtizVerónica Ruiz-SalasPedro Sánchez-SambucetyJosé L López-EstebaranzRafael Botella-EstradaCarlos Feal-CortizasAntonio Martorell CalatayudPilar GilVictoriano Morales-GordilloAgustí Toll-AbellóIzascun Ocerin-GuerraMatías Mayor-ArenalCarmen Garcia-DonosoNatividad Cano-MartinezLaura Sainz-GasparMiguel A DescalzoIgnacio Garcia-Dovalnull null
Published in: Experimental dermatology (2021)
Characterization of patients, surgery procedures and the risk factors for dermatofibrosarcoma protuberans (DFSP) recurrences is poorly defined. In this study, we aimed to describe the demographics, tumor characteristics and interventions of DFSP treated with Mohs micrographic surgery (MSS) to determine the rate and risk factors for recurrence. Data were collected from REGESMOHS, a nationwide prospective cohort study of patients treated with MMS in Spain. From July 2013 to February 2020, 163 patients with DFSP who underwent MMS were included. DFSP was mostly located on trunk and extremities. Recurrent tumors had deeper tumor invasion and required higher number of MMS stages. Paraffin MMS was the most frequently used technique. Overall recurrence rate was 0.97 cases/100 person-years (95% IC = 0.36-2.57). No differences were found in epidemiological, tumor, surgery characteristics or surgical technique (frozen or paraffin MMS [p = 0.6641]) in terms of recurrence. Median follow-up time was 28.6 months with 414 patient-years of follow-up. In conclusion, we found an overall low recurrence rate of DFSP treated with MMS. None of the studied risk factors, including MMS techniques, was associated with higher risk for recurrence.
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