Effect of a new cyclic derivative of GABA, RGPU-207, on the functions of cardiac and cerebral mitochondria of stressed animals.
Ivan Sergeevich MokrousovValentina Nikolaevna PerfilovaIgor Igorevich ProkofievTamara Alexandrovna PopovaEkaterina Gennadievna VodopyanovaOlga Sergeevna Vasil'evaIvan Nikolaevich TyurenkovPublished in: The Journal of pharmacy and pharmacology (2019)
Twenty-four-hour immobilization and pain stress activate LPO processes inhibit the activity of the aos enzymes and decrease the functional activity of cardiac and cerebral mitochondria. RGPU-207 restricts LPO, enhances the antioxidant enzyme activity and improves the mitochondrial respiration. The efficacy of RGPU-207 is comparable with phenibut and piracetam.