Achieving Fast Charge Separation by Ferroelectric Ultrasonic Interfacial Engineering for Rapid Sonotherapy of Bacteria-Infected Osteomyelitis.
Jianfang LiXiangmei LiuYufeng ZhengZhenduo CuiHui JiangZhaoyang LiShengli ZhuShui-Lin WuPublished in: Advanced materials (Deerfield Beach, Fla.) (2023)
Bacteria-infected osteomyelitis is life-threatening without effective therapeutic methods clinically. Here, a rapid and effective therapeutic strategy to treat osteomyelitis through ferroelectric polarization interfacial engineering of BiFeO 3 /MXene (Ti 3 C 2 ) triggered by ultrasound (US) is reported. Under US, the ferroelectric polarization induces the formation of the piezoelectric field. US cavitation effect induced sonoluminescence stimulates BiFeO 3 /Ti 3 C 2 to produce photogenerated carriers. With synergistic action of the polarization electric field and Schottky junction, BiFeO 3 /Ti 3 C 2 accelerates the separation of electrons and holes and simultaneously inhibits the backflow of electrons, thus improving the utilization of polarized charges and photogenerated charges and consequently enhancing the yield of reactive oxygen species under US. As a result, 99.87 ± 0.05% of Staphylococcus aureus are efficiently killed in 20 min with the assistance of ultrasonic heating. The theory of ferroelectric ultrasonic interfacial engineering is proposed, which brings new insight for developing ferroelectric ultrasonic responsive materials used for the diagnosis and therapy of deep tissue infection and other acoustoelectric devices.
Keyphrases
- staphylococcus aureus
- reactive oxygen species
- ionic liquid
- molecular dynamics simulations
- cancer therapy
- electron transfer
- magnetic resonance imaging
- perovskite solar cells
- high glucose
- stem cells
- diabetic rats
- computed tomography
- biofilm formation
- pseudomonas aeruginosa
- drug induced
- cystic fibrosis
- stress induced
- methicillin resistant staphylococcus aureus
- cell therapy
- smoking cessation