Hypoproliferative human neural progenitor cell xenografts survived extendedly in the brain of immunocompetent rats.
Chunhua LiuXiaoyun WangWenhao HuangWei MengZhenghui SuQi XingHeng ShiDi ZhangMin ZhouYifan ZhaoHaitao WangGuangjin PanXiaofen ZhongDuanqing PeiYiping GuoPublished in: Stem cell research & therapy (2021)
The present study confirms the "immune privilege" of the brain parenchyma and, more importantly, unveils that choosing hypoproliferative NPCs for transplantation can benefit graft outcome in terms of both lower tumor-genic risk and the prolonged survival time without immunosuppression.