INHBA is a mediator of aggressive tumor behavior in HER2+ basal breast cancer.
Moqing LiuRebecca SmithTiera LibyKami ChiottiClaudia S LópezJames E KorkolaPublished in: Breast cancer research : BCR (2022)
Our data suggest that INHBA is associated with aggressiveness of the basal subtype of HER2+ tumors, resulting in poor response to HER2-targeted therapy and an invasive phenotype. We hypothesize that targeting this pathway could be an effective therapeutic strategy to reduce invasiveness of tumor cells and to improve therapeutic response.