Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study.

C E LeursHam TwaalfhovenB I Lissenberg-WitteV van PeschI DujmovicJ DrulovicMassimiliano CastellazziT BelliniM PugliattiJ KuhleL M VillarJ C Alvarez-CermeñoRoberto Álvarez-LafuenteH HegenFlorian DeisenhammerL M WalchhoferE ThouvenotM ComabellaX MontalbanL VécseiC RajdaD GalimbertiE ScarpiniA AltintasK RejdakJ L FrederiksenG Pihl-JensenPeh JensenMicheal Khalil Margarete Maria VoortmanF FazekasAlbert SaizD La PumaM VercammenL VanopdenboschBmj UitdehaagJ KillesteinC BridelC Teunissen

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2019)

Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS.

Keyphrases

mass spectrometry
multiple sclerosis
ms ms
nuclear factor
immune response
inflammatory response