Genetic deletion of platelet PAR4 results in reduced thrombosis and impaired hemostatic plug stability.

Robert Hugh Lee Tomohiro KawanoSteven P GroverVanthana BharathiDavid MartinezDale O CowleyNigel MackmanWolfgang BergmeierSaravanan Subramaniam

Published in: Journal of thrombosis and haemostasis : JTH (2021)

We generated a novel PAR4fl/fl ;PF4Cre+ mouse line. We used this mouse line to show that PAR4 signaling in platelets is critical for arterial and venous thrombosis and hemostatic plug stability.

Keyphrases

pulmonary embolism
genome wide
gene expression
copy number
dna methylation