Childhood Cerebral Adrenoleukodystrophy: MR Perfusion Measurements and Their Use in Predicting Clinical Outcome after Hematopoietic Stem Cell Transplantation.

Alexander M McKinney John C Benson David R Nascene Julie B Eisengart M B Salmela D J Loes Lei Zhang K Patel G V Raymond Weston P Miller

Published in: AJNR. American journal of neuroradiology (2016)

Leading enhancing edge measurements likely remain normal post-hematopoietic stem cell transplantation in cerebral adrenoleukodystrophy, suggesting local disease stabilization. Meanwhile, parieto-occipital WM and splenium of the corpus callosum relative CBV and relative CBF values worsened; this change signified irreversible injury. Baseline splenium of the corpus callosum relative CBV may predict clinical outcomes following hematopoietic stem cell transplantation.

Keyphrases

acute myeloid leukemia
subarachnoid hemorrhage
contrast enhanced
magnetic resonance imaging
brain injury