Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.
Debjani GuhaDavid R LorenzVikas MisraSukrutha ChettimadaSusan MorgelloDana GabuzdaPublished in: Journal of neuroinflammation (2019)
These findings suggest that CSF EVs derived from neurons, glial cells, and choroid plexus carry synaptic, immune/inflammation-related, and stress response proteins in HIV+ individuals with cognitive impairment, representing a valuable source for biomarker discovery.
Keyphrases
- cognitive impairment
- antiretroviral therapy
- cerebrospinal fluid
- hiv positive
- hiv infected
- hiv testing
- oxidative stress
- human immunodeficiency virus
- induced apoptosis
- hepatitis c virus
- hiv aids
- men who have sex with men
- small molecule
- cell cycle arrest
- prefrontal cortex
- south africa
- spinal cord
- high throughput
- endoplasmic reticulum stress
- cell proliferation
- cell death
- neuropathic pain
- pi k akt
- single cell