Molecular docking and pharmacokinetic studies of phytocompounds from Nigerian Medicinal Plants as promising inhibitory agents against SARS-CoV-2 methyltransferase (nsp16).

Tolulope Peter SaliuHaruna I UmarOlawale Johnson OgunsileMicheal O OkparaNoriyuki YanakaOlusola Olalekan Elekofehinti

Published in: Journal, genetic engineering & biotechnology (2021)

Our findings suggest that the six phytocompounds could serve as therapeutic agents to prevent viral survival and replication in cells. However, further studies on the in vitro and in vivo inhibitory activities of these 6 hit phytocompounds against SARS-CoV-2 nsp16 are needed to confirm their efficacy and dose.

Keyphrases

sars cov
molecular docking
respiratory syndrome coronavirus
induced apoptosis
case control
molecular dynamics simulations
cell cycle arrest
signaling pathway
cell proliferation
oxidative stress
free survival
coronavirus disease