Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis.
Gabriela Vivili Domingues SilvaEder da Silva DolensLívia Máris Ribeiro ParanaíbaAna Lúcia Carrinho AyrozaClarissa Araujo Gurgel RochaAlhadi AlmangushTuula SaloPeter A BrennanRicardo Della ColettaPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2022)
Our findings support tumor-stroma ratio as a potential prognostic marker for patients with oral squamous cell carcinoma, and the incorporation of tumor-infiltrating lymphocytes into the World Health Organization grading system improves the prognostic ability of the tumor grading alone.